Efecto de los fitoestrógenos del extracto acuoso del aguaje (Mauritia flexuosa L.) en ratones hembra Mus musculus ovariectomizadas
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Abstract
Due to the possible adverse complications of hormonal therapy during menopause, alternative therapies based on plants have been chosen for their phytosterol content. The aim of the study was to evaluate the effect of phytoestrogens from the aqueous extract of aguaje (Mauritia flexuosa L.) in ovariectomized female Mus musculus mice. The research had an experimental design. 15 female mice (Mus musculus) of the BALC/c strain, four weeks old, weighing 25 to 35 g, were used, randomly assigned to three groups: G1 or control: without ovariectomization, they received only sterile water; G2: ovariectomized; They were administered 600 mg/mL of aqueous extract of aguaje 100% saturation in sterile water (1mL/100 g) and G3: ovariectomized; They were administered 1200 mg/mL of aqueous extract of aguaje, 50% saturation in sterile water (0.5 mL/10 g). ANOVA was applied to the data obtained with a statistical significance level p:<0.05. The dose that exerted trophic effects on the parameters analyzed (weight of the uterine horn and oviduct) was the dose of 1200 mg/mL. There was no significant difference between initial and final weight between groups, nor in the weight and length of the uterine horn; However, a significant difference (p: <0.05) was observed for oviduct weight between groups. The phytoestrogens from the aqueous extract of aguaje (Mauritia flexuosa L.) could be considered as an alternative hormonal therapy during the menopause stage.
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