Efficacy of fluorides for the prevention of dental caries: a narrative review
Main Article Content
Abstract
In dentistry, fluoride has reduced the prevalence of dental caries infection, both in children and adults. The aim was to evaluate the effectiveness of fluorides for the prevention of dental caries, through its mechanism of action, routes of administration and adverse effects due to its indiscriminate application. A narrative review type study was carried out and PICO questions were developed for its development. The search was carried out in databases such as PubMed, Lilacs, and the Google Scholar search engine; RAYYAN web application was used. Fluoride is widely used in dentistry, within clinical practice there are sodium fluoride, stannous fluoride, and acidulated phosphate fluoride. This mineral can be administered in two forms, systemic and topical; However, its indiscriminate use can cause dental fluorosis and poisoning. It is concluded that the application of fluoride, combined with policies that promote oral health, would reduce caries rates in the intervened populations. Furthermore, constant training of the dentist will increase success in the application of fluorides, avoiding adverse effects.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Agarwal, D., Purohit, B., Ravi, P., Priya, H., & Kumar, V. (2022). Effectiveness of topical fluorides in prevention of radiation caries in adults: A systematic review and meta-analysis. Oral Oncology, 129, 105869. doi: https://doi.org/10.1016/j.oraloncology.2022.105869.
Araya, D., Podgorski, J., Kumi, M., Mainoo, P., & Berg, M. (2022). Fluoride contamination of groundwater resources in Ghana: Country-wide hazard modeling and estimated population at risk. Water Research, 212,118083. https://doi.org/10.1016/j.watres.2022.118083.
Astasov, M., & Kulik, E. (2021). Cariogenic Biofilms and Caries from Birth to Old Age. Monographs in Oral Science, 29,53-64. doi: https://doi.org/10.1159/000510200.
Batsos, C., Boyes, R., & Mahar, A. (2021). Community water fluoridation exposure and dental caries experience in newly enrolled members of the Canadian Armed Forces 2006-2017. Canadian Journal of Public Health, 112(3), 513-520. doi: https://doi.org/10.17269/s41997-020-00463-7.
Brown, P., Fox, K., Field, E., & Randall, C. (2021). UK Dental Medicines Advisory Service: questions asked by dentists - part 4: prescribing of high-strength fluoride toothpastes and use of fluoride varnishes in dental practice. British Dental Journal, 231(10), 623-628. doi: https://doi.org/10.1038/s41415-021-3664-x.
Buzalaf, M. (2018). Review of Fluoride Intake and Appropriateness of Current Guidelines. Advances in Dental Research, 29(2), 157-166. doi: https://doi.org/10.1177/0022034517750850.
Camargo, M., Palencia, L., Santaella, J., & Suárez, L. (2020). El uso de fluoruros en niños menores de 5 años. Evidencia. Revisión bibliográfica. Revista de Odontopediatría Latinoamericana, 10(1), https://backup.revistaodontopediatria.org/ediciones/2020/1/art-8/.
Chan, A., Tamrakar, M., Jiang, C., Tsang, Y., Leung, K., & Chu, C. (2022). Clinical evidence for professionally applied fluoride therapy to prevent and arrest dental caries in older adults: A systematic review. Journal of Dentistry, 125,104273. doi: https://doi.org/10.1016/j.jdent.2022.
Dong, H., Yang, X., Zhang, S., Wang, X., Guo, C., Zhang, X., Ma, J., Niu, P., & Chen, T. (2021). Associations of low level of fluoride exposure with dental fluorosis among U.S. children and adolescents, NHANES 2015-2016. Ecotoxicology and Environmental Safety, 221, 112439. doi: https://doi.org/10.1016/j.ecoenv.2021.112439. 221:112439.
Farhad, F., Kazemi, S., Bijani, A., & Pasdar, N. (2021). Efficacy of Theobromine and Sodium Fluoride Solutions for Remineralization of Initial Enamel Caries Lesions. Frontiers in dentistry, 18,10. doi: https://doi.org/10.18502/fid. v18i10.6134.
Foley, M., Sexton, C., Spencer, A., Lalloo, R., Do, L. (2022). Water fluoridation, dental caries, and parental ratings of child oral health. Community Dentistry and Oral Epidemiology, 50(6), 493-499. doi: https://doi.org/10.1111/cdoe.12697.
Gil, A., & Bidlack, F. (2020). Tooth Enamel and its Dynamic Protein Matrix. International Journal of Molecular Sciences, 21(12):4458. doi: https://doi.org/10.3390/ijms21124458.
Gumber, H., Louyakis, A., Sarma, T., Fabijanic, K., Paul, R., Mellenbruch, K., & Kilpatrick, L. (2022). Effect of a Stannous Fluoride Dentifrice on Biofilm Composition, Gene Expression and Biomechanical Properties. Microorganisms,10(9),1691. doi: https://doi.org/10.3390/microorganisms10091691.
Gupta, A., Nishant, N., Sharda, S., Kumar, A., Goyal, A., Gauba, K. (2020). Comparing the Effectiveness of Topical Fluoride and Povidone Iodine with Topical Fluoride Alone for the Prevention of Dental Caries among Children: A Systematic Review and Meta-analysis. International Journal of Clinical Pediatric Dentistry, 13(5):559-565. doi: https://doi.org/10.5005/jp-journals-10005-1844.
James, P., Harding, M., Beecher, T., Browne, D., Cronin, M., Guiney, H., O’Mullane, D., & Whelton, H. (2021). Impact of Reducing Water Fluoride on Dental Caries and Fluorosis. Journal of Dental Research, 100(5), 507-514. doi: https://doi.org/10.1177/0022034520978777.
Jullien, S. (2021). Prophylaxis of caries with fluoride for children under five years. BMC Pediatrics,21(Suppl 1), 351. https://doi.org/10.1186/s12887-021-02702-3.
Kanmodi, K., Nwafor, J., Salami, A., Egbedina, E., Nnyanzi, L., Ojo, T., Duckworth, R., & Zohoori, F. (2022). A Scopus-Based Bibliometric Analysis of Global Research Contributions on Milk Fluoridation. International Journal of Environmental Research and Public Health, 19(14), 8233. doi: https://doi.org/10.3390/ijerph19148233.
Koberová, R., Radochová, V., Kovácsová, F., & Merglová, V. (2021). Exogenous Intake of Fluorides in Caries Prevention: Benefits and Risks. Acta Medica (Hradec Kralove), 64(2), 71-76. doi: https://doi.org/10.14712/18059694.2021.13.
Lancaster, P., Carmichael, F., Clerehugh, V., & Brettle, D. (2022). Emissivity evaluation of human enamel and dentin. Frontiers in physiology, 13, 993674. doi: https://doi.org/10.3389/fphys.2022.993674.
Lubojanski, A., Piesiak, D., Zakrzewski, W., Dobrzynski, W., Szymonowicz, M., Rybak, Z., Mielan, B., Wiglusz, R., Watras, A., & Dobrzynski, M. (2023). The Safety of Fluoride Compounds and Their Effect on the Human Body-A Narrative Review. Materials, 16(3):1242. doi: https://doi.org/10.3390/ma16031242.
Lucchese, A., Bertacci, A., Lo Giudice, A., Polizzi, E., Gherlone, E., Manuelli, M., Chersoni, S., Moro, D., & Valdrè, G. (2020). Stannous Fluoride Preventive Effect on Enamel Erosion: An In Vitro Study. Journal of Clinical Medicine, 9(9), 2755. doi: https://doi.org/10.3390/jcm9092755.
Mani, D., Vinay, C., Uloopi, K., RojaRamya, K., Penmatsa, C., & Chandana, N. (2022). Evaluation of caries arresting potential of silver diamine fluoride and sodium fluoride varnish in primary molars: A randomized controlled trial. Journal of the Indian Society of Pedodontics and Preventive Dentistry, 40(4), 377-382. doi: https://doi.org/10.4103/jisppd.jisppd_239_22.
Maraver, F., Vitoria, I., Almerich, J., & Armijo, F. (2015). Fluoruro en aguas minerales naturales envasadas en España y prevención de la caries dental. Atención Primaria, 47(1),15-24. https://doi.org/10.1016/j.aprim.2014.04.003.
Martignon, S., Roncalli, A., Alvarez, E., Aránguiz, V., Feldens, C., & Buzalaf, M. (2021). Risk factors for dental caries in Latin American and Caribbean countries. Brazilian Oral Research,35 (suppl 1), e053. doi: https://doi.org/10.1590/1807-3107bor-2021.vol35.0053.
Mascarenhas, A. (2021). Is fluoride varnish safe? Validating the safety of fluoride varnish. The Journal of the American Dental Association, 152(5),364-368. doi: https://doi.org/10.1016/j.adaj.2021.01.013.
Motohashi, J., Taguchi, C., Song, W., Kawamura, K., Arakawa, H., Kawagoe, M., & Tsurumoto, A. (2022). Development of small-scale water fluoridation equipment. Journal of Oral Science, 64(4), 283-285. doi: https://doi.org/10.2334/josnusd.21-0541.
O’Hagan, K., Enax, J., Meyer, F., & Ganss, B. (2022). The use of hydroxyapatite toothpaste to prevent dental caries. Odontology, 110(2), 223-230. https://doi.org/10.1007/s10266-021-00675-4.
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid A. (2010). Rayyan—a web and mobile app for systematic reviews. Systematic Reviews,5(1), 210. https://doi.org/10.1186/s13643-016-0384-4.
Pérez, R., Armendáriz, C., Fernández, Á., Paz, S., Hardisson, A. (2020). Niveles de fluoruro en dentífricos y colutorios. Journal of Negative and No Positive Results, 5(5),491-503. https://dx.doi.org/10.19230/jonnpr.3326.
Pitts, N., Twetman, S., Fisher, J., & Marsh, P. (2021). Understanding dental caries as a non-communicable disease. British Dental Journal, 231(12), 749 - 53. https://doi.org/10.1038/s41415-021-3775-4.
Raghavan, A., Sukumaran, A., & Parangimalai, M. (2022). Effectiveness of Nanoparticle-Based Acidulated Phosphate Fluoride (APF) Gel on Surface Enamel Fluoride Uptake: an Interventional Study. Journal of Dentistry (Shiraz Iran), 23(1), 40-50. doi: https://doi.org/10.30476/DENTJODS.2021.87895.1295.
Razafimamonjy, L., Chuy, V., Ranivoharilanto, E., Decroix, B., & Holmgren, C. (2019). Fluoride in drinking water in Madagascar and the development of a strategy for salt fluoridation. Community Dental Health, 36(3), 214-220. doi: https://doi.org/10.1922/CDH_4549Razafimamonjy07.
Revelo, I., Hardisson, A., Rubio, C., Gutiérrez, Á., Paz, S. (2021). Dental Fluorosis: the Risk of Misdiagnosis-a Review. Biological trace element research, 199(5), 1762-1770. doi: https://doi.org/10.1007/s12011-020-02296-4.
Roberts, W., Mangum, J., & Schneider, P. (2022). Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection. Current Osteoporosis Reports, 20(1),106 - 19. doi: https://doi.org/10.1007/s11914-022-00723-0.
Saldarriaga, A., Rojas, D., Restrepo, M., Santos, L., & Jeremias, F. (2021). Dental fluorosis severity in children 8-12 years old and associated factors. Acta Odontológica Latinoamericana,34(2), 156-65. doi: https://doi.org/10.54589/aol.34/2/156.
Satou, R., Yamagishi, A., Takayanagi, A., Iwasaki, M., Kamijo, H., & Sugihara, N. (2022). Improved Enamel Acid Resistance by Highly Concentrated Acidulated Phosphate Sodium Monofluorophosphate Solution. Materials,15(20),7298. doi: https://doi.org/10.3390/ma15207298.
Schiffner, U. (2021). Use of fluorides for caries prevention. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 64(7), 830-837. doi: https://doi.org/10.1007/s00103-021-03347-4.
Sharda, S., Gupta, A., Goyal, A., & Gauba K. (2021). Remineralization potential and caries preventive efficacy of CPP-ACP/Xylitol/Ozone/Bioactive glass and topical fluoride combined therapy versus fluoride mono-therapy - a systematic review and meta-analysis. Acta Odontologica Scandinavica, 79(6),402 - 17. doi: https://doi.org/10.1080/00016357.2020.1869827.
Valdivia, A., Botelho, J., Giacaman, R., Tabchoury, C, & Cury, J. (2021). Fluoride concentration in mouth rinses marketed in Chile and Brazil, and a discussion regarding their legislations. Brazilian Oral Research,35, e083. doi: https://doi.org/10.1590/1807-3107bor-2021.vol35.0083.
Wegehaupt, F., & Menghini, G (2020). Fluoride Update. Swiss Dental Journal, 130(9), 677-683. https://pubmed.ncbi.nlm.nih.gov/32893610/.
Whelton, H., Spencer, A., Do, L., & Rugg, A. (2019). Fluoride Revolution and Dental Caries: Evolution of Policies for Global Use. Journal of Dental Research, 98(8), 837-846. doi: https://doi.org/10.1177/0022034519843495.
Zhen, L., Liang, K., Luo, J., Ke, X., Tao, S., Zhang, M., Yuan, H., He, L., Bidlack, F., Yang, J., & Li, J. (2022). Mussel-Inspired Hydrogels for Fluoride Delivery and Caries Prevention. Journal of Dental Research, 101(13),1597 - 1605. doi: https://doi.org/10.1177/00220345221114783.
Zokaie, T., & Pollick, H. (2022). Community water fluoridation and the integrity of equitable public health infrastructure. Journal of Public Health Dentistry, 82(3),358 - 61. doi: https://doi.org/10.1111/jphd.12480.